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An inorganic chemical, titanium dioxide is used as a dye to help products achieve a certain appearance, including whitening a product. Some experts and publications have described it as being akin to a paint primer that's used before the color is added to food in order to give products a uniform shine. Its presence is common in many items beyond Skittles including coffee creamers, cake mixes, and chewing gum. It's also used for pigment and in cosmetics manufacturing.

The future of TiO₂

I don't see the scientific evidence in the literature that would cause people any concern, said Kaminski.

Analyst Insight

In conclusion, calcium carbonate and titanium dioxide are important minerals that are used in various industries. While they are both produced by manufacturers, they have different manufacturing processes and applications. Understanding the differences between these two minerals can help industries make informed decisions about which one to use for their specific needs.

The annual production capacity of high-grade rutile titanium dioxide has reached more than 400,000 tons. It is one of the largest TiO2 manufacturers in China at present. It has more than ten product brands of Taiohua, Jinxing and other brands, and its products are sold in more than 50 countries and regions around the world. It has long maintained the excellent performance of the second overall ranking in the domestic titanium dioxide industry.

History

TiO₂ NPs appeared to be more toxic to nematode Caenorhabditis elegans than submicron-sized TiO_2.  At a concentration of 1 mg/l, 7 nm particles affected its fertility and survival rate and were more toxic than 20 nm anatase particles. Similarly, Hu et al. showed that rutile particles (10–20 nm), at concentrations above 1 g/kg soil, can be bio-accumulated in earthworms, where they induce oxidative stress, inhibit the activity of cellulase and induce DNA and mitochondrial damage.

The evidence also suggests that the toxicity of TiO₂ particles may be reduced when eaten as part of the diet. This is because proteins and other molecules in a person's diet can bind to the TiO₂ particles. This binding alters the physical and chemical properties of the particles, which influences how they interact with cells, tissues and organs.

Australian researchers examined how titanium dioxide as a food additive affected gut microbiota in mice by orally administering it in drinking water. The study, published in the journal Frontiers in Nutrition in 2019, found the treatment could “alter the release of bacterial metabolites in vivo and affect the spatial distribution of commensal bacteria in vitro by promoting biofilm formation. We also found reduced expression of the colonic mucin 2 gene, a key component of the intestinal mucus layer, and increased expression of the beta defensin gene, indicating that titanium dioxide significantly impacts gut homeostasis.” The changes were then linked to colonic inflammation, along with a higher expression of inflammatory cytokines, which are signal proteins that help with regulation. The researchers concluded that titanium dioxide “impairs gut homeostasis which may in turn prime the host for disease development.”

Lithopone 30% increases extruder performance and reduces processing costs, improves quality and is suitable for masterbatch for injection of Polyolefins, ABS, Polycarbonate, Polypropylene, Polyethylene, Polystyrene, single layer films, multi-layer films and for white, coloured and filled masterbatch. The combination of Lithopone 30 with TiO2 results in improved mechanical properties including higher elongation values and better impact resistance.