In conclusion, wholesale anatase titanium dioxide is an essential ingredient for coatings that require UV resistance and chemical stability. By purchasing in bulk from a reliable supplier, businesses can take advantage of cost savings and ensure a steady supply of this important ingredient for their production needs. Whether it's for outdoor applications or industrial settings, anatase titanium dioxide is a versatile and effective component in coatings that delivers long-lasting protection and durability.

In an early study Jani et al. administred rutile TiO₂ (500 nm) as a 0.1 ml of 2.5 % w/v suspension (12.5 mg/kg BW) to female Sprague Dawley rats, by oral gavage daily for 10 days and detected presence of particles in all the major gut associated lymphoid tissue as well as in distant organs such as the liver, spleen, lung and peritoneal tissue, but not in heart and kidney. The distribution and toxicity of nano- (25 nm, 80 nm) and submicron-sized (155 nm) TiO₂ particles were evaluated in mice administered a large, single, oral dosing (5 g/kg BW) by gavage. In the animals that were sacrificed two weeks later, ICP-MS analysis showed that the particles were retained mainly in liver, spleen, kidney, and lung tissues, indicating that they can be transported to other tissues and organs after uptake by the gastrointestinal tract. Interestingly, although an extremely high dose was administrated, no acute toxicity was observed. In groups exposed to 80 nm and 155 nm particles, histopathological changes were observed in the liver, kidney and in the brain. The biochemical serum parameters also indicated liver, kidney and cardiovascular damage and were higher in mice treated with nano-sized (25 or 80 nm) TiO₂ compared to submicron-sized (155 nm) TiO₂. However, the main weaknesses of this study are the use of extremely high single dose and insufficient characterisation of the particles.

The price of Titanium Dioxide in Taiwan rose considerably throughout December 2018, reaching 3,750 USD per metric ton.  The price in Taiwan is 10% higher than the average price in the previous month and 1% higher than the average price one year before. In contrast, Titanium Dioxide prices in India were flat during December 2018, and were decline when compared to the average price in the preceding yeara decline of 3% from the previous year’s price. 

Lithopone: an alternative to titanium dioxide

Still, you may wonder whether it’s safe for consumption.

The paints and coatings industry reduced their offtakes which coupled with the drop in the crude oil prices and availability of cheaper imports from the Asian market led to the fall in titanium dioxide prices. The demand decreased significantly in the fourth quarter along with the slow manufacturing due to high inflation rates keeping the price trends of the commodity in the negative zone.

Opportunities

What's the Verdict?

In 2016, the European Food Safety Authority, or EFSA, assessed titanium dioxide and determined that the evidence available at the time didn’t conclusively point to any health problems for consumers. 

TiO2 is a white pigment that is commonly used in the production of paints, plastics, and paper. It is known for its brightness, opacity, and durability, making it an ideal choice for products that require a high level of whiteness and coverage. TiO2 is also used in sunscreen lotions and cosmetics to provide protection against harmful UV rays. In addition, TiO2 is used in the food industry as a food additive to enhance the appearance of products such as candies and confectionery.

A 2022 review on past studies of titanium dioxide and rat lung cancer, for instance, said the original study was under extreme conditions and its effects were not replicated in other animal species. Additionally, the review concluded that the few studies which did directly focus on titanium dioxide's impact on humans did not end up showing any increased cancer risk.

In conclusion, lithopone is an important white pigment that is used in a variety of industries around the world. With 30% of the world's lithopone factories located in China, the country has become a major player in the global lithopone market. Chinese manufacturers are able to produce high-quality lithopone at a competitive price, making it an attractive option for companies looking to reduce their production costs. Despite the challenges of production, China's lithium industry continues to thrive and innovate, ensuring a stable and reliable supply of this essential pigment for years to come.