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  • Prof. Matthew Wright, chair of EFSA’s working group on E171, noted: “Although the evidence for general toxic effects was not conclusive, on the basis of the new data and strengthened methods we could not rule out a concern for genotoxicity and consequently we could not establish a safe level for daily intake of the food additive.”

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  • ↑ Revenir plus haut en :a et b Völz, Hans G. et al.Pigments, Inorganic in Ullmann's Encyclopedia of Industrial Chemistry, 2006, Wiley-VCH, Weinheim, DOI 10.1002/14356007.a20_243.pub2.
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  • For research published in 2022 study in the journal Food and Chemical Toxicology, scientists examined “the genotoxicity and the intracellular reactive oxygen species induction by physiologically relevant concentrations of three different TiO2 nanomaterials in Caco-2 and HT29-MTX-E12 intestinal cells, while considering the potential influence of the digestion process in the NMs’ physiochemical characteristics.” They found a “DNA-damaging effect dependent on the nanomaterial,” along with the micronucleus assay suggesting “effects on chromosomal integrity, an indicator of cancer risk, in the HT29-MTX-E12 cells, for all the tested TiO2 nanomaterials.” Researchers concluded that the results showcase “evidence of concern” regarding titanium dioxide used as a food additive.

  • Sachtleben's journey into the world of TiO2 production began with a clear vision to manufacture high-performance pigments that not only meet but exceed industry standards. Their commitment to excellence is evident in the rigorous processes employed at their state-of-the-art facilities. Using cutting-edge technology, they have refined the traditional chloride process for producing TiO2, ensuring unparalleled purity and consistent color strength in their products.
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  • 5. Regulatory compliance The MSDS should also include information on regulatory requirements for the safe handling and use of lithopone, including any permits or certifications that may be necessary.


  • Manufacturers of products with titanium dioxide play a critical role in the industry by ensuring that their products meet the highest quality and safety standards. These manufacturers must adhere to strict guidelines set forth by regulatory agencies to ensure that their products are safe for consumer use. Additionally, manufacturers must also invest in research and development to continually improve their products and stay ahead of the competition.