It is added to these materials to improve their strength, durability, and resistance to UV radiation It is added to these materials to improve their strength, durability, and resistance to UV radiationtitanium dioxide powder uses suppliers. Reliable suppliers of titanium dioxide powder play a key role in helping manufacturers of plastic and rubber products meet the performance and quality standards demanded by customers.The most significant uncertainty identified by the EU experts was the concern that TiO2 particles may have genotoxic effects. Genotoxicity refers to the ability of a chemical to directly damage genetic material within a cell (DNA), which may lead to cancer in certain situations. Although the experts did not conclude that TiO2 particles in E171 are genotoxic, they could not rule out the concern that they might be.
For research published in Archives of Toxicology in 2020, scientists fed one group of mice a solution containing titanium dioxide for one month, and compared it to those that did not receive the additive. They found “the richness and evenness of gut microbiota were remarkably decreased and the gut microbial community compositions were significantly changed” in the titanium dioxide group when compared with the control group. The tests also revealed that the titanium dioxide exposure could cause locomotor dysfunction, or mobility issues “by elevating the excitement of enteric neurons, which might spread to the brain via gut-brain communication by vagal pathway.” The researchers concluded: “These findings provide valuable insights into the novel mechanism of TiO2NP-induced neurotoxicity. Understanding the microbiota-gut-brain axis will provide the foundation for potential therapeutic or prevention approaches against TiO2NP-induced gut and brain-related disorders.”