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  • In a study published in the journal Environmental Toxicology and Pharmacology in 2020, researchers examined the effects of food additives titanium dioxide and silica on the intestinal tract by grouping and feeding mice three different food-grade particles — micro-TiO2, nano-TiO2, and nano-SiO2.  With all three groups, researchers observed changes in the gut microbiota, particularly mucus-associated bacteria. Furthermore, all three groups experienced inflammatory damage to the intestine, but the nano-TiO2 displayed the most pronounced changes. The researchers wrote: “Our results suggest that the toxic effects on the intestine were due to reduced intestinal mucus barrier function and an increase in metabolite lipopolysaccharides which activated the expression of inflammatory factors downstream. In mice exposed to nano-TiO2, the intestinal PKC/TLR4/NF-κB signaling pathway was activated. These findings will raise awareness of toxicities associated with the use of food-grade TiO2 and SiO2.”

  • The first step in the process is the grinding of the ore to a fine powder. This powder is then mixed with chlorine and sulfuric acid in a reactor to form titanium tetrachloride (TiCl4). This compound is a key intermediate in the production of titanium dioxide.
  • To overcome this challenge, manufacturers use advanced technology and processes to monitor and control the buff percentage of their products. This may involve the use of sophisticated equipment to measure the coating thickness of titanium dioxide particles, as well as automated systems to adjust the level of coating as needed. By carefully controlling the buff percentage, manufacturers can ensure that their products meet the specifications of their customers and maintain a high level of quality and performance.


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  • Titanium Dioxide for Nitrile Gloves A Comprehensive Supplier Guide
  • The Scientific Committee on Consumer Safety (SCCS) warns against sprayable products and powders that may expose users’ lungs to titanium dioxide through inhalation (10).

  • Despite being produced in China, both calcium carbonate and titanium dioxide are also important import commodities for the country. China imports calcium carbonate from countries like Vietnam, Indonesia, and Malaysia, while it imports titanium dioxide from countries like Germany, Japan, and the United States.
  • In addition to pigments and sunscreens, titanium dioxide is also used in the production of paper, food products, and pharmaceuticals. In the paper industry, titanium dioxide is added to paper coatings to improve brightness, smoothness, and printability. In the food industry, titanium dioxide is used as a whitening agent in products such as candies, chewing gum, and icing. In the pharmaceutical industry, titanium dioxide is used as a coloring agent in tablets and capsules.


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  • Given its widespread use, finding reliable suppliers of barium sulphate is crucial for industries that rely on this compound. Many companies specialize in the production and distribution of barium sulphate, ensuring that businesses can source high-quality materials tailored to their specific needs.