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Titanium dioxide is one of the many oxides formed naturally in our environment. Manufacturers source this mined mineral from rutile, brookite, and anatase. It is then processed and refined to meet stringent safety guidelines based on the end-use for the mineral. 

EINECS accession number: 215-715-5

Well asides from making you re-think that M & M addiction (chocolate coated in Titanium Dioxide…..anyone?!)

≥100

Below 20% substitution, it is recommended to replace 1 kg of TiO2 with 1 kg of lithopone supplier.  

For those wishing to limit or avoid exposure to titanium dioxide in foods, there are some steps you can take. 

Different dermal cell types have been reported to differ in their sensitivity to nano-sized TiO₂ . Kiss et al. exposed human keratinocytes (HaCaT), human dermal fibroblast cells, sebaceous gland cells (SZ95) and primary human melanocytes to 9 nm-sized TiO₂ particles at concentrations from 0.15 to 15 μg/cm² for up to 4 days. The particles were detected in the cytoplasm and perinuclear region in fibroblasts and melanocytes, but not in kerati-nocytes or sebaceous cells. The uptake was associated with an increase in the intracellular Ca²⁺ concentration. A dose- and time-dependent decrease in cell proliferation was evident in all cell types, whereas in fibroblasts an increase in cell death via apoptosis has also been observed. Anatase TiO₂ in 20–100 nm-sized form has been shown to be cytotoxic in mouse L929 fibroblasts. The decrease in cell viability was associated with an increase in the production of ROS and the depletion of glutathione. The particles were internalized and detected within lysosomes. In human keratinocytes exposed for 24 h to non-illuminated, 7 nm-sized anatase TiO_2, a cluster analysis of the gene expression revealed that genes involved in the “inflammatory response” and “cell adhesion”, but not those involved in “oxidative stress” and “apoptosis”, were up-regulated. The results suggest that non-illuminated TiO₂ particles have no significant impact on ROS-associated oxidative damage, but affect the cell-matrix adhesion in keratinocytes in extracellular matrix remodelling. In human keratinocytes, Kocbek et al. investigated the adverse effects of 25 nm-sized anatase TiO₂ (5 and 10 μg/ml) after 3 months of exposure and found no changes in the cell growth and morphology, mitochondrial function and cell cycle distribution. The only change was a larger number of nanotubular intracellular connections in TiO₂-exposed cells compared to non-exposed cells. Although the authors proposed that this change may indicate a cellular transformation, the significance of this finding is not clear. On the other hand, Dunford et al. studied the genotoxicity of UV-irradiated TiO₂ extracted from sunscreen lotions, and reported severe damage to plasmid and nuclear DNA in human fibroblasts. Manitol (antioxidant) prevented DNA damage, implying that the genotoxicity was mediated by ROS.

Panzhihua Dongfang TiO2 manufacturer has 28 patents related to titanium dioxide production by sulfuric acid method, 3 research results, and 5 registered trademarks. Excellent quality, excellent covering power, excellent system dispersion, good whiteness, high brightness, and low oil absorption. The company’s products are exported to more than 40 countries and regions in the world, and the export ratio is nearly 40%. It is the second largest exporter in Panzhihua City after Panzhihua Iron and Steel. Top 50, Sichuan Enterprise Technology Center, Panzhihua Municipal Government “Advanced Foreign Trade Export Enterprise” and other titles

Lithopone B301, Lithopone B311 Powder

Titanium dioxide is an insoluble mineral, meaning it cannot dissolve in water. Known for its bright, white pigment, manufacturers use titanium dioxide in many different capacities, including in cosmetics, foods, and drugs.