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  • Different dermal cell types have been reported to differ in their sensitivity to nano-sized TiO2 . Kiss et al. exposed human keratinocytes (HaCaT), human dermal fibroblast cells, sebaceous gland cells (SZ95) and primary human melanocytes to 9 nm-sized TiO2 particles at concentrations from 0.15 to 15 μg/cm2 for up to 4 days. The particles were detected in the cytoplasm and perinuclear region in fibroblasts and melanocytes, but not in kerati-nocytes or sebaceous cells. The uptake was associated with an increase in the intracellular Ca2+ concentration. A dose- and time-dependent decrease in cell proliferation was evident in all cell types, whereas in fibroblasts an increase in cell death via apoptosis has also been observed. Anatase TiO2 in 20–100 nm-sized form has been shown to be cytotoxic in mouse L929 fibroblasts. The decrease in cell viability was associated with an increase in the production of ROS and the depletion of glutathione. The particles were internalized and detected within lysosomes. In human keratinocytes exposed for 24 h to non-illuminated, 7 nm-sized anatase TiO2, a cluster analysis of the gene expression revealed that genes involved in the “inflammatory response” and “cell adhesion”, but not those involved in “oxidative stress” and “apoptosis”, were up-regulated. The results suggest that non-illuminated TiO2 particles have no significant impact on ROS-associated oxidative damage, but affect the cell-matrix adhesion in keratinocytes in extracellular matrix remodelling. In human keratinocytes, Kocbek et al. investigated the adverse effects of 25 nm-sized anatase TiO2 (5 and 10 μg/ml) after 3 months of exposure and found no changes in the cell growth and morphology, mitochondrial function and cell cycle distribution. The only change was a larger number of nanotubular intracellular connections in TiO2-exposed cells compared to non-exposed cells. Although the authors proposed that this change may indicate a cellular transformation, the significance of this finding is not clear. On the other hand, Dunford et al. studied the genotoxicity of UV-irradiated TiO2 extracted from sunscreen lotions, and reported severe damage to plasmid and nuclear DNA in human fibroblasts. Manitol (antioxidant) prevented DNA damage, implying that the genotoxicity was mediated by ROS.

  • The Asian market was favorable to the rising price trends of titanium dioxide in the first quarters of 2023. The prices inclined gradually with some slight fluctuations. The positive outlook of the market was a direct effect of removing covid restrictions, upscaling industrial production, and high speed of market recovery.

  • The primary function of TiO2 in pigment production is its exceptional ability to provide brightness and opacity. When added to paints or coatings, it enhances their hiding power by reflecting light back to the observer's eye. This property not only improves the aesthetic appeal of the product but also reduces the amount of colorant needed, resulting in cost savings for manufacturers. Moreover, TiO2's high refractive index ensures that even small quantities can significantly impact the final appearance of the product.
  • In conclusion, the titanium dioxide price chart serves as a vital tool for stakeholders within the industry. By analyzing past trends and current market conditions, businesses can make informed decisions about when to buy or sell this crucial material. It is clear that a multitude of factors—from production costs and supply-demand dynamics to global economic health and geopolitical developments—all contribute to shaping the titanium dioxide market and its ever-changing price landscape.
  • TR 28 titanium dioxide is used in a wide range of applications, including paints, coatings, plastics, and paper. In paints and coatings, it provides excellent coverage and durability, making it a popular choice for interior and exterior applications. In plastics, it adds whiteness and opacity while also improving the material's UV resistance.
  • Thirdly, the supplier's pricing and delivery terms should also be taken into consideration
  • As a food additive, titanium dioxide and its nanoparticles in particular have been associated with DNA damage and cell mutations, which in turn, have potential to cause cancer. When used as a food coloring, it is known as E171.