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  • Breathing problems in offspring

  • The vitaminC@P25TiO2NPs, on the other side, did not have any effect on cell protection against ROS. This might be due to the fact that vitamin C, a well-known scavenger of ROS, could behave as prooxidant and even promote ROS and lipid peroxidation [39]. It was recently described that at small concentrations of vitamin C, the prooxidant effects dominate; while in large concentrations the antioxidant ones predominate [40]. The effect also depends on the cell state and the interaction of vitamin C with light. In this case, ascorbic acid may act as an antenna to harvest visible light when conjugated to P25TiO2NPs. Indeed, it was previously found that this combination (in some ratios) could have an improved photocatalytic activity, possibly due to a red shift in its light absorbance [41]. Further studies on vitaminC@P25TiO2NPs were not conducted, because of the poor antioxidant capacity [42].

  • Titanium dioxide holds exceptional significance as a white pigment due to its superior scattering capabilities, remarkable chemical stability, and non-toxic nature. Among all white pigments, it surpasses others in terms of its ability to scatter light effectively. Consequently, titanium dioxide stands as the most significant inorganic pigment, accounting for the highest quantity in usage. The majority part of the global production of ilmenite and rutile is dedicated to the production of TiO2 pigments. The remaining portion is utilized for the manufacturing of titanium metal and in the production of welding electrodes.

  • R-5566:

  • ≤0.3

  • Another important application of titanium dioxide is in the production of self-cleaning surfaces
  • Prof. Matthew Wright, chair of EFSA’s working group on E171, noted: “Although the evidence for general toxic effects was not conclusive, on the basis of the new data and strengthened methods we could not rule out a concern for genotoxicity and consequently we could not establish a safe level for daily intake of the food additive.”

  • Therefore, today, they only recommend limiting titanium dioxide inhalation in industries with high dust exposure, such as paper production (11).

  • Chloride process. This process requires a high titanium feedstock. Rutile is reacted with hydrochloric acid to produce titanium tetrachloride, which can be hydrolyzed with steam or oxidized with air to render the dioxide. A rutile form of titanium dioxide is obtained.