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  • While considered safe for consumption by the FDA, there is growing concern about the safety of titanium dioxide among consumer advocacy groups, with European countries recently banning the additive.
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  • Tronox Limited is another major player in the rutile market, with operations in Australia, South Africa, and the United States. The company's rutile production is used for the manufacture of titanium metal, which is in high demand for its strength, lightness, and corrosion resistance. Tronox Limited is also a leading producer of titanium dioxide pigments, which are used in the production of paints, coatings, and plastics
    rutile
    rutile market manufacturers.
  • Ref. 18% TiO2
  • In conclusion, titanium dioxide is a versatile and widely used ingredient in the cosmetics industry. Its benefits include broad-spectrum sun protection, natural pigmentation, chemical stability, and non-irritating properties. While there are some safety concerns regarding its use, regulatory agencies have established guidelines to ensure its safe use in cosmetic products. As the demand for natural and safe cosmetic products continues to grow, the future outlook for TiO2 in the cosmetics industry looks promising.
  • On the supply side, titanium is primarily produced from two sources ilmenite and rutile. Ilmenite is the most common source of titanium ore, while rutile is considered a higher-grade source. The supply of titanium ore is influenced by factors such as mining regulations, environmental concerns, and geopolitical events. Any disruptions in the supply chain can have a significant impact on prices.
  • A safety review conducted by the EFSA in 2021 assessed thousands of studies published on titanium dioxide.

  • In 2023, California and New York proposed banning several food additives that are banned in Europe but legal in the United States. Titanium dioxide was among the five proposed to be banned, but in September, the additive was removed from the list of additives from the California ban list.

  • Chemical resistance is another key property of R1930, making it suitable for use in a wide range of environments. It is resistant to acids, bases, and solvents, which means that it can withstand the conditions often encountered in printing processes. This makes R1930 an ideal choice for inks that will be used in harsh environments, such as outdoor signage or packaging materials that may come into contact with chemicals.
  • 10. ISK Bioxsys A Korean company that produces TIO2 pigments for use in cosmetics, food, and pharmaceuticals.
  • China's dominance in the production of titanium dioxide is largely due to its vast mineral reserves and advanced processing technology. With a focus on achieving a minimum purity of 98%, Chinese manufacturers are able to produce high-quality titanium dioxide that meets the stringent requirements of various industries. This commitment to excellence has helped China establish itself as a global leader in the production of titanium dioxide.
  • On the other hand, the U.S. Food and Drug Administration (FDA) in their Final Administrative Order on Sunscreen Drug Products posted in September 2021 still accepts titanium dioxide up to 25% in the list of Generally Recognized As Safe and Effective (GRASE) in the main document, without further clarification on what kind or size of particles [9]. However, on page 24 (Sunscreen containing nanomaterials) FDA clearly “distinguish nanomaterials from other forms of these ingredients'' (zinc oxide and titanium dioxide) and ask for comments on “any particular nanomaterials that you believe should not be permitted for use in OTC sunscreen products”. To the best of our knowledge, this Agency did not ban the use of nanoparticulate titanium dioxide in any form, even though it is mentioned on page 34 that the anatase form is the more photoactive one, due to the lack of evidence with real sunscreens OTC (over the counter) in vivo. Moreover, other regulations in Latin America (MERCOSUR agreement, 2006) do not state clearly their position on the use of nanoparticulate TiO2NPs [10].

  • Fig. 2. SEM micrograph and EDS map of the same area of a vitaminB2@P25TiO2NPs.

  • Nanotoxicology