There is some concern regarding skin and intestinal absorption of titanium dioxide nanoparticles, which are less than 100 nm in diameter.

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Titanium Dioxide/TiO2/Titanium Oxide Free Sample
Risk managers at the European Commission and in EU Member States have been informed of EFSA’s conclusions and will consider appropriate action to take to ensure consumers’ protection.
The properties of lithopone are very suitable for use in the production of coatings. Because the ingredients of lithopone are zinc sulfide and barium sulfate, and the more zinc sulfide content, the stronger its covering power. This indicates a paint product with strong white covering power. It is different from water in that it reacts with acid but does not react with alkali. It has a wide range of uses. Because its structural properties are similar to titanium dioxide and its price is relatively cheap, it can also be used as a substitute for some titanium dioxide. Lithopone can be used for coloring paints, inks, pigments, rubber, paper, leather, enamel, etc.
Sunscreens and cosmetics containing titanium dioxide are generally considered safe since they are mineral-based products. Mineral products are often recommended for acne-prone and sensitive skin. However, there have been some concerns that titanium dioxide may have a negative impact on health.
Titanium dioxide is often used as a UV absorber and pigment in cosmetic products, such as foundations, lipsticks, creams, sunscreens and other skin care products. It helps protect the skin from the harmful effects of UV rays by blocking them, while providing a brightening effect.
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